Voiding dysfunction related to adverse childhood experiences and neuropsychiatric disorders
نویسندگان
چکیده
منابع مشابه
Voiding Dysfunction in Childhood
Urologists are often asked to attend a child with wetting or voiding problems. These are the more common paediatric conditions seen in a urology clinic. The child may have enuresis, voiding frequency or incontinence. Although a majority of these cases run a benign course, it is necessary to differentiate them from others that may develop into serious complication, namely upper urinary tract dam...
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REELIN (RELN) is a large (420 kDa) glycoprotein that in adulthood is mostly synthesized in GABAergic neurons of corticolimbic structures. Upon secretion in the extracellular matrix (ECM), RELN binds to VLDL, APOE2, and α3β2 Integrin receptors located on dendritic shafts and spines of postsynaptic pyramidal neurons. Reduced levels of RELN expression in the adult brain induce cognitive impairment...
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Recent studies have shown that multiple categories of retrospectively reported childhood adverse events often co-occur (Finkelhor et al., 2007) and, in many cases, they are nonspecific in their associations with different mental disorders (Green et al., 2010). On this basis, the latest studies (Green et al., 2010) are aimed to assess various forms of abuse simultaneously and to examine multiple...
متن کاملAdverse childhood experiences, allostasis, allostatic load, and age-related disease.
How do adverse childhood experiences get 'under the skin' and influence health outcomes through the life-course? Research reviewed here suggests that adverse childhood experiences are associated with changes in biological systems responsible for maintaining physiological stability through environmental changes, or allostasis. Children exposed to maltreatment showed smaller volume of the prefron...
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Mitochondrial disorders were first described in 1962 (Luft, Ikkos, Palmieri, Ernster, & Afzelius, 1962), and were initially thought to be uniformly progressive and fatal with onset in infancy or early childhood, typically associated with severe neurological manifestations, including strokelike episodes, seizures, neuronal degeneration, organ failure and dementia. More recently, clinical observa...
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ژورنال
عنوان ژورنال: Journal of Pediatric Urology
سال: 2014
ISSN: 1477-5131
DOI: 10.1016/j.jpurol.2014.06.012